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Table 2: Antibiotics recommended for chemoprophylaxis and eradication of nasopharyngeal carriage of N. meningitidis.

Age Group

Reference*

Antibiotics

Dosages

Adults

Adults

CCDM
AAP

Rifampin**

600 mg by mouth twice daily for 2 days

Adults

CCDM

Ceftriaxone***

250 mg intramuscularly, single dose

Adults $18 years

CCDM

Ciprofloxacin

500 mg by mouth, single dose

Children

Children #1 month

AAP
CCDM

Rifampin

5 mg/kg by mouth every 12 hours for two days

Children >1 month

AAP
CCDM

Rifampin

10 mg/kg by mouth every 12 hours for two days (maximum dose 600 mg)

Children <15 years

CCDM

Ceftriaxone***

125 mg intramuscularly, single dose

Children <12 years

AAP

* CCDM: Control of Communicable Disease Manual, 16th edition. American Public Health Association, 1995. AAP: American Academy of Pediatrics, Report of the Committee on Infectious Diseases, 1994 Red Book.

** Single dose ciprofloxacin and ceftriaxone now are considered to be reasonable alternatives to rifampin.

***CCDM and AAP differ on the recommended age limits for children receiving ceftriaxone. Ceftriaxone is the drug of choice during pregnancy.

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